Growth hormone (GH) reaches its peak in the late teens and early twenties, after which it begins to decline. IGF-1 is produced and released by the liver in response to growth hormone. IGF-1 increases growth in all cells, including muscle, bones, and organs, while circulating in the blood.
Increases in IGF-1 due to increased growth hormone production have the following consequences:
- Building muscular mass, which improves strength
- Burning fat for energy boosts energy and endurance while also keeping weight under control
- Bone density improvement
- Stimulating the production of male and female sex hormones and promoting testicular growth and development increase your ability to exercise.
- Increasing heart muscle strength
- Wrinkle prevention through thickening the skin
It’s easy to see the connection between the functions of growth hormone, the decline in growth hormone levels as we age, and aging symptoms. This is why studies into the potential of peptides as anti-aging agents are underway.
Sermorelin is a secretagogue that secretes growth hormones. Sermorelin is made up of the first 29 amino acids (protein building blocks) of GHRH. Sermorelin promotes the pituitary gland’s normal secretion of growth hormone. When you inject a growth hormone secretagogue, unlike growth hormone injections, the body’s usual hormone checks and balances remain intact. It decreases fatigue, deterioration of existing muscles, improves injury healing and increases metabolism, energy level, mineralization, bone density and muscle mass.
Ipamorelin is a GH secretagogue that works in conjunction with Sermorelin by acting on a separate receptor. Sermorelin resembles ghrelin, while ghrelin mimics GHRH. It raises growth hormone levels by acting on both the hypothalamus and the pituitary. Ghrelin impacts metabolism, inhibits stored fat breakdown, and stimulates the release of growth hormones via increasing hunger. It increases bone density, body fat loss, and muscle mass.
Combination of Sermorelin and Ipamorelin
The use of a combination of sermorelin ipamorelin peptides may be the most effective way to elicit maximum growth hormone release. Sermorelin is a newly created counterpart to the growth hormone-releasing hormone (GHRH). It not only preserves the benefits of natural GHRH, but it also helps to alleviate some of its drawbacks. Similarly, recent investigations have found that ipamorelin is the most selective and targeted counterpart of the ghrelin/growth hormone secretagogue. When these peptides are combined, they work together to maximise growth hormone production. The synergy increases the benefits of GH for brain function, protein synthesis, cardiac stability, and digestion. However, this peptides blend is only for research purpose.
The usage of ghrelin and ghrelin substitutes lowers the risk of ventricular disease and speeds up the healing process after a heart attack.
The peptide combination of sermorelin and ipamorelin has particular GH-related benefits. In comparison to other GH-releasing peptides, these effects are more apparent. Sermorelin has been proven in animal tests to have a favourable effect on the central nervous system, which improves sleep quality. On the other hand, Ipamorelin has been related to improved bone health, diabetes insulin balance, and bowel movement (especially post-surgery).
It is currently exclusively available for research and academic usage by Biotech Peptides, not for clinical human consumption.